There are always a lot of discussions on the various RV forums (Outbackers.com, TrailerLife.com, etc.) about gas mileage, how to increase gas mileage, and how much it costs to take trips in these vehicles. Interestingly, it does not really matter if you are talking about a travel trailer, a 5th wheel trailer, a Class C or a Class A motorhome, as all of these vehicles get about the same mileage; 7 to 10 miles per gallon (for gas vehicles - diesels can be a bit higher).
I tracked our gasoline useage on several recent trips. The first trip was 1,700 miles through Northern California and Oregon, to Pasco, Washington. We bought 212.4 gallons of gasoline on this trip, for a grand total of $575.01. That we got 8 miles per gallon surprised me a bit, since we had to traverse the Siskyou Summit at 4,310 feet, and several other passes along the way.
On our last trip, I was able to use our new ScanGauge to measure the fuel economy. This allowed me to be a little more accurate on the fuel consumption, so I decided to measure the affect of speed on the mileage. I would drive normally on the 150 mile trip to the campground - "normally" being around 65mph. On the trip home, over the same route, I would keep the speed down to 60mph. The result was a gain of 0.5 miles per gallon, from 8.8mpg over 150 miles at 65mph, to 9.3 miles per gallon over 150 miles at 60mph. The route was mostly freeway, but included a 1,700 foot pass over the coastal mountain range, and about 10 miles of urban stop-and-go driving.
Is there more to be had? I could slow down to 55mph, but that might be dangerous on the California Highway System! I doubt there is much more to be gained, since at the end of the day the engine is still just trying to push a big box through the air.